You have to use Control Panel -> Sound to make the Audiobox the default recording and/or playback device.The Windows device manager shows the Audiobox as a separate entry called 'PreSonus USB Audio 2.0 Devices' rather than a device under Sound, Video, and Game Controllers.The second installation and reboot worked.

The first time I installed it and rebooted Windows 10 didn't recognize the device. The Universal Control software doesn't request a reboot as it says in the documentation.I had to switch to Firefox to get the menu to work correctly. Chrome wasn't showing me the drop-down menu option to register hardware instead of software.I changed it to a simple password with no special characters and the problems disappeared. It is weird but I would just like to open pro tools on the default ‘internal’ and playnot have to click on another source and the click internal. A strong password generated by a password manager program was causing a great deal of frustration, working some of the time and getting rejected some of the time. Each time I open pro tools I have to change internal to anyone of the sources (sp/diff or any other) and then click internal again to get sound.I was having a lot of trouble getting my Audiobox USB and software registered and working until I discovered some things:

Pro tools not recognizing interface